Advances in Biochemical Engineering, Volume 003 by T.K. Ghose ,A. Fiechter, N.Blakebrough PDF

By T.K. Ghose ,A. Fiechter, N.Blakebrough

ISBN-10: 0387065466

ISBN-13: 9780387065465

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I i I I I ! ~'_~ '" . . . . . . . . . . . . . . • Fig. 20. , 1971) a genetic analysis as loci responsible for the biosynthesis of the antibiotic. The important genes responsible for the formation of tetracyclines may thus belong to different, frequently independent, metabolic pathways. A common feature of these loci is the final effect of their action-provision of intermediates for the biosynthetic process. Van~k et al. e. the transformation of the hypothetical tricyclic nonaketide, 56 z.

1971b, 1972). It appears that repeated mutagenic treatment during several-step preparation of multiple mutants for the analysis of secondary metabolism can result in the accumulation of unknown blocks in primary metabolism affecting indirectly also secondary biosynthetic pathway. This multiple damage then cannot be repaired by a single recombination in one locus. This assumption is supported by the fact that many low-production mutants of S. , 1972). 44 Z. HO~ALEK et al. c) Interspecific Recombination Most papers dealing with interspecific recombination between S.

It appears that repeated mutagenic treatment during several-step preparation of multiple mutants for the analysis of secondary metabolism can result in the accumulation of unknown blocks in primary metabolism affecting indirectly also secondary biosynthetic pathway. This multiple damage then cannot be repaired by a single recombination in one locus. This assumption is supported by the fact that many low-production mutants of S. , 1972). 44 Z. HO~ALEK et al. c) Interspecific Recombination Most papers dealing with interspecific recombination between S.

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Advances in Biochemical Engineering, Volume 003 by T.K. Ghose ,A. Fiechter, N.Blakebrough


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