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By Jeese P. Greenstein, Alexander Haddow (Eds.)

ISBN-10: 0120066033

ISBN-13: 9780120066032

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Evans calculates that an activity of 3 X lop6 pc. m. per working day t o the epithelium of the larger bronchi. m. Shapiro (1954) and Anderson, Mayneord, and Turner (1955) point out that Evans ignored the effect of the particulate matter in the air bearing the radioactive breakdown products of radon and they estimate that the total dose received by some areas of the bronchi is likely to have been 70 times higher. m. (Evans, 1950), the physical data may be considered reasonably consistent with the hypothesis that the Jachymov cancers were due to exposure to radon in the air.

1952) found that large calcified foci-larger than in any other part of the lung-were present in the same lobe as the tumor, * If the entire population of miners and retired miners observed by gikl is assumed to have been aged 25 to 44 years, the comparable mortality among nonsmokers would be 20 per million. ETIOLOGY O F LUNG CANCER 45 or in the tracheobronchial nodes draining the lobe, in 27 out of 40 cases of squamous and anaplastic bronchial cancer. They suggested that calcified foci might increase the susceptibility of the neighboring bronchial mucosa to carcinogenic substances reaching it from the inspired air, or that bronchiectasis following primary tuberculosis might be a predisposing factor.

Doll and Hill (1952) compared the history of previous respiratory disease in 1465 patients with carcinoma of the lung and in 853 patients with cancer in other sites. After making allowance for the age and sex of the patients they found that the proportions of patients complaining of attacks of respiratory tuberculosis, pleural effusion, asthma, or chronic nasal catarrh more than five years previously were practically the same in both groups, but that the proportions complaining of chronic bronchitis or of pneumonia more than five years previously were significantly greater in the lung carcinoma group.

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Advances in Cancer Research, Vol. 3 by Jeese P. Greenstein, Alexander Haddow (Eds.)


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