Advances in Virus Research, Volume 88 - download pdf or read online

By Karl Maramorosch, Frederick A. Murphy

ISBN-10: 0128000988

ISBN-13: 9780128000984

The first assessment sequence in virology and released considering 1953, Advances in Virus Research covers a various diversity of in-depth stories, supplying a important evaluate of the sphere.

  • Contributions from top authorities
  • Comprehensive stories for normal and professional use
  • First and longest-running evaluate sequence in virology

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Additional resources for Advances in Virus Research, Volume 88

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To reduce these technical limitations, a set of minimal requirements for RNAi screens have been established. This includes a rigorous validation process based on two or more siRNAs targeting different sites in the mRNA of interest and showing the same phenotype. , 2005). 2. Protein interaction networks A complementary approach to identify host factors involved in a viral replication cycle is the analysis of protein interaction networks. Two methods Revisiting Dengue Virus–Host Cell Interaction 29 that are frequently used are based on high-throughput yeast two-hybrid assays or coaffinity purification followed by mass spectrometry.

2003). , 2006). , 1994). , 2003). Experiments designed to decipher the mode of action of DC-SIGN for DENV entry revealed that this factor is dispensable for virus internalization. , 2003). Thus, DC-SIGN acts as a DENV attachment factor, which might facilitate the interaction of virus particles with a cellular receptor responsible for internalization. , 2006). , 2005). , 2011). Two independent studies of patient cohorts from Thailand and Taiwan show a strong association with genotypes 42 Eliana G.

Among them, heparan sulfate proteoglycan (HSPG) and nucleophosmin showed decreased abundance, whereas superoxide Revisiting Dengue Virus–Host Cell Interaction 33 dismutase, cyclophilin A, and a-enolase amounts were enhanced. Interestingly, a-enolase is known to serve as a strong plasminogen receptor and activator. , 2008). Proteome analyses have also been conducted with mosquito cells. , 2011). , 2011). , 2012). , 2009). , 2012). One aspect that has often been ignored in the past is the dependency of viruses on distinct host cell lipids.

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Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy

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