By Philip J. Brooks PhD (auth.), Samir Zakhari, Vasilis Vasiliou, Q. Max Guo (eds.)
The global healthiness association has pointed out persistent alcohol intake as one of many best ten danger components for around the globe burden of affliction. The overseas organisation for examine on melanoma has pointed out alcohol as carcinogenic to people, together with cancers of the higher aerodigestive tract, colon, liver and breast. Alcohol’s activities might be direct e.g. results on retinoic acid and one-carbon metabolism, or oblique, via metabolites akin to acetaldehyde and reactive oxygen species or via a number of signaling pathways that impact phone cycle and apoptosis which can give a contribution to carcinogenesis. This quantity experiences the cutting-edge in alcohol-related melanoma examine in ten chapters.
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Extra info for Alcohol and Cancer
2007; Siegel and Zhu 2009). The linkage between obesity and the rising incidence of hepatocellular carcinoma is supported by several observations: the timing of the adult obesity epidemic and the rising incidence of HCC are approximately concurrent over the last 25 years 3 Alcohol and Cancer Epidemiology 25 Fig. 3 Liver disease mortality as a function of BMI and alcohol consumption in men (data from Hart et al. 2010) Units = 10 g ethanol. 5% among women (Flegal et al. 2010) is sufficient to have a large impact.
One factor contributing to this increase in liver cancer is that it is the result of the increasing impact of viral hepatitis (mainly HCV) during the 1990s (El-Serag and Mason 2000; El-Serag et al. 2004). T. Gentry Fig. 2 HHC: Annual age-adjusted incidence rates per 100,000 and trends, all hepatocellular carcinoma cases and by sex, 1975–2005 (Surveillance, Epidemiology, and End Results 9, SEER9) (from Altekruse et al. 2009) patients in the USA (55–78%) remained seronegative for both HCV and HBV (El-Serag et al.
Siegel AB, Zhu AX (2009) Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 115:5651–61. Singal AK, Anand BS (2007) Mechanisms of synergy between alcohol and hepatitis C virus. Clin Gastroenterol 41(8):761–72. Su LJ, Arab L (2004) Alcohol consumption and risk of colon cancer: evidence from the national health and nutrition examination survey I epidemiologic follow-up study. Nutr Cancer 50:111–9. Sumathi B, Ramalingam S, Navaneethan U, Jayanthi V (2009) Risk factors for gastric cancer in South India.
Alcohol and Cancer by Philip J. Brooks PhD (auth.), Samir Zakhari, Vasilis Vasiliou, Q. Max Guo (eds.)