By David R. Gross DVM, PhD (auth.)
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Additional info for Animal models in cardiovascular research
The second dose reduced the decline in ventricular fibrillation threshold caused by LAD occlusion. 5:1 Dogs Pentobarbital anesthetized (30 Ilglkg Ilg/kg IV) n=12 lOOllglkg lOOllg/kg Increased R -R interval, atrial HIS interval, paced atrial-HIS interval, AV nodal effective refractory period, AV nodel functional refractory period and retrograde ventricular effective refractory period. No change in HIS-ventricle interval. 115 Same 4OOllg/kg 400llglkg Same as above with larger increases in most cases 115 Isolated hindlimb preparation, halothane anesthesia n=5 5,30 and 50 Ilglkg Ilg/kg of limb weight Apparent dose-dependent decrease in resistance which was significant only at high doses in both innervated and dennervated limbs.
There was no change in systemic resistance or pulmonary arterial wedge pressure 13 Same as above with addition of 10 glkg, IV propranolol 15 mg/kg, IV Heart rate decreased but all other Reart parameters did not change. 1:1 Dogs Induction with thiopentone (10 mglkg, IV), 70% nitrous oxide, 30% oxygen 4 mglkg, mg/kg, IV Severe and rapid fall in peripheral perfusion as measured by skeletal muscle musc1e surface pH. pR. e. 5 mg/kg, mglkg, S. C. 5 mg/kg, mglkg, IV Decrease in heart rate but less than same dose given intracisternal injection.
1:4 Rabbits Anesthetized with urethane (lglkg, (lg/kg, IV) plus 30 min. 1:5 Hamsters Anesthetized with pentobarbital (no dose given), exposed in vivo cheek pouch preparation, superfused with Krebs solution Dose response Dose-dependent arterioles dilation of 35 Same as above 10-8 to 109M superfusate Caused vasodilation but betaendorphan 55 x more potent net enkephalin 24x, leu enkephalin 20 x 133 Analgesia and sedation 2-5 mglkg, mg/kg, SC Effects within 15 min. of SC injection. No cardiovascular data provided.
Animal models in cardiovascular research by David R. Gross DVM, PhD (auth.)