Antibiotic Resistance: Understanding and Responding to an by Karl S. Drlica, David S. Perlin PDF

By Karl S. Drlica, David S. Perlin

ISBN-10: 0131387731

ISBN-13: 9780131387737

As pathogenic micro organism evolve, antibiotic resistance is spreading, compromising our skill to regulate and deal with infectious illnesses. Antibiotic Resistance completely illuminates this significant factor for healthcare pros, researchers, scholars, and policymakers. major investigators clarify what resistance is, the way it emerges, which human actions give a contribution, and the way to reinforce our defenses.

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Extra info for Antibiotic Resistance: Understanding and Responding to an Emerging Crisis

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The pile of tumor cells is called a focus. Foci can be seen and counted using a low-power microscope. The concentration of tumor viruses is then estimated by knowing the extent of dilution and volumes of virus samples applied to the Petri dish. Some other viruses cause cells to fuse into giant cells called syncytia that can also be seen and counted using a low-power microscope. Thus, the biological properties of pathogens are used to estimate their numbers. Many pathogens can be handled safely in ordinary microbiology laboratories.

The aminoglycosides bind to ribosomal proteins and ribosomal RNA, thereby blocking a variety of steps in protein synthesis. com 38 Antibiotic Resistance streptomycin, one of our oldest antibiotics, attaches to a protein of the small ribosome subunit and locks the mRNA-ribosome complex in place. That prevents proper movement of mRNA across the ribosome and leads to incorporation of incorrect amino acids into new protein. Other members of this class are kanamycin, gentamycin, and tobramycin. The tetracyclines first came to market in the 1940s, and over the years they cured many millions of infections.

Treatment of E. coli with these agents almost completely protects the bacterium from the lethal action of oxolinic acid, an early type of quinolone. Thus, the idea is emerging that lethal signals caused by antibiotics trigger a cascade of reactive oxygen species that are responsible for much of the cell death. 73 That raises the possibility for making inhibitors of the protective enzymes that will enhance the lethal activity of many antibiotics. Although such enhancers have not yet been developed, small-molecule additives have proven successful for β-lactams such as penicillin.

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Antibiotic Resistance: Understanding and Responding to an Emerging Crisis by Karl S. Drlica, David S. Perlin


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