By Margaret Ackerman, Falk Nimmerjahn
Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to steer the immune reaction. The ebook demonstrates the significance of the Fc area, together with protecting mechanisms, effector telephone kinds, genetic facts, and variability in Fc area functionality. This quantity is a serious single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.
Antibodies signify the correlate of safety for various vaccines and are the main quickly turning out to be category of gear, with purposes starting from melanoma and infectious illness to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are accountable for antigen reputation, and will supply safety through blocking off the functionality in their goal antigen. even if, fresh advancements in our realizing of the safety mediated by way of antibodies have highlighted the serious nature of the antibody consistent, or Fc area, within the organic task of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, delivering specificity to a variety of innate effector cells. furthermore, they supply a suggestions loop to manage the nature of the immune reaction through interactions with B cells and antigen-presenting cells.
- Clarifies different mechanisms of IgG job on the point of different version structures used, together with human genetic, mouse, and in vitro
- Covers the position of antibodies in melanoma, infectious sickness, and autoimmunity and within the surroundings of monoclonal antibody remedy in addition to evidently raised antibodies
- Color illustrations improve causes of the immune system
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Additional info for Antibody Fc. Linking Adaptive and Innate Immunity
Immunology 2012;136(3):291–305. Joller N, Weber SS, Müller AJ, Spörri R, Selchow P, Sander P, et al. Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting. Proc Nat Acad Sci USA 2010;107(47):20441–6. de Valliere S, Abate G, Blazevic A, Heuertz RM, Hoft DF. Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies. Infect Immun 2005;73(10):6711–20. Armstrong JA, Hart PD. Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli.
Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by γ-interferon is mediated through common DNA response elements. Proc Nat Acad Sci USA 1991;88(24):11305–9. Quan Y, Möller T, Weinstein JR. Regulation of Fcγ receptors and immunoglobulin G-mediated ANTIBODY Fc 42 2. Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control phagocytosis in mouse microglia. Neurosci Lett 2009;464(1):29–33. Platt CD, Ma JK, Chalouni C, Ebersold M, BouReslan H, Carano RA, et al.
Immune complex-induced enhancement of bacterial antigen presentation requires Fcγ receptor III expression on dendritic cells. Proc Nat Acad Sci USA 2007;104(33):13402–7. Riquelme SA, Bueno SM, Kalergis AM. IgG keeps virulent Salmonella from evading dendritic cell uptake. Immunology 2012;136(3):291–305. Joller N, Weber SS, Müller AJ, Spörri R, Selchow P, Sander P, et al. Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting. Proc Nat Acad Sci USA 2010;107(47):20441–6.
Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn