Download PDF by Robert L. LaFemina: Antiviral research : strategies in antiviral drug discovery

By Robert L. LaFemina

ISBN-10: 1555814395

ISBN-13: 9781555814397

ISBN-10: 1555815499

ISBN-13: 9781555815493

Captures the country of the technological know-how with twenty reports that research the most recent in today’s antiviral drug discovery efforts.

  • Presents the elemental ideas of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes scientific elements of viral an infection in regards to therapy and toxicity.
  • Examines recognized and power ambitions in any respect phases of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a vast diversity of viruses, together with HIV-1, HSV, and HCV.

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Extra info for Antiviral research : strategies in antiviral drug discovery

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Hwang, Y. -Y. Liu, D. M. Coen, and C. B. C. Hwang. 1997. Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. J. Virol. 71:7791–7798. 85. Ilsley, D. -H. Lee, W. H. Miller, and R. D. Kuchta. 1995. Acyclic guanosine analogues inhibit DNA polymerases a, d, and  with very different potencies and have unique mechanisms of action. Biochemistry 34:2504–2510. 86. Irmiere, A. , M. M. Manos, J. G. Jacobson, J.

S. Taylor, and J. M. Sowadski. 1991. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253:414–420. 92. , R. Mirchev, D. E. Golan, A. M. van Oijen, and D. M. Coen. 2008. Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc. Natl. Acad. Sci. USA 105:10721–10726. 93. Krosky, P. -C. Baek, W. J. Jahng, I. Barrera, R. J. Harvey, K. K. Biron, D. M. Coen, and P. B. Sethna. 2003. The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase.

Darby. 1987. Related functional domains in virus DNA polymerases. EMBO J. 6:169–175. 98. , A. D. Stuart, and M. S. Chee. 1992. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 358:160–162. 99. , J. D. Knafels, J. S. Chang, G. A. Waszak, E. T. Baldwin, M. R. , D. R. Thomsen, F. L. Homa, P. A. Wells, M. C. Tory, R. A. Poorman, H. Gao, X. Qiu, and A. P. Seddon. 2006. Crystal structure of the herpes simplex virus 1 DNA polymerase.

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Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina


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